| CAS | 204656-20-2 |
| Sequence | H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-(γ-Glu-palmitoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH |
| Sequence Single | HAEGTFTSDVSSYLEGQAA-Lys-(γ-Glu-palmitoyl)-EFIAWLVRGRG |
| Molecular Formula | C172H265N43O51 |
| Molecular Weight | 3751.24 |
| Synonyms | NN2211 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Diabetes |
| Description | Liraglutide also called NN2211, is a highly potent, long-acting GLP-1 receptor agonist (EC50 = 61 pM). Acylated derivative of GLP-1 (7-37). Inhibits food and water intake, causing lasting and reversible weight loss in normal and obese rats. |
| References | 1. Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration. Knudsen et al (2000). J.Med.Chem. 43 1664 PMID: 10794683 2. Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats. Larsen et al (2001). Diabetes 50 2530 PMID: 11679431 |