| CAS | 125580-28-1 |
| Sequence | H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2 |
| Sequence Single | YPSKPDNPGEDAPAEDLARYYSALRHYINLLTRPRY-NH2 |
| Molecular Formula | C190H286N54O56 |
| Molecular Weight | 4222.69 |
| Synonyms | [Leu31, Pro34] Neuropeptide Y (1-36), porcine |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Obesity Research |
| Description | (Leu31,Pro34)-Neuropeptide Y (porcine) also called [Leu31, Pro34] Neuropeptide Y (1-36), porcine, is a NPY analog, it is a highly potent and selective ligand for Y1 receptors in different cell lines and tissues. It has therefore been used to detect the NPY/PYY receptor subtype distribution, e.g., in rat brain. The peptide is also active in vivo, showing an even higher potency than NPY in increasing blood pressure in anesthetized rats. |
| References | 1. [Leu31-Pro34] neuropeptide Y identifies a subtype of 125I-labeled peptide YY binding sites in the rat brain. A.M.L.Castrucci et al., Drugs Future, 15, 41 (1990) 2. [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist. D.R.Gehlert et al., Neurochem. Int., 21, 45 (1992) 3. [Leu31-Pro34] neuropeptide Y identifies a subtype of 125I-labeled peptide YY binding sites in the rat brain. J.Fuhlendorff et al., Proc. Natl. Acad. Sci. USA, 87, 182 (1990) 4. Interaction between neuropeptide Y and alpha-melanocyte stimulating hormone in amygdala regulates anxiety in rats. Kokare DM, et, al. Brain Res. 2005 May 10;1043(1-2):107-14. |
(Leu31,Pro34)-Neuropeptide Y (porcine)
CAS No.: 125580-28-1
(Leu31,Pro34)-Neuropeptide Y (porcine) also called [Leu31, Pro34] Neuropeptide Y (1-36), porcine, is a NPY analog, it is
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