Laminin α-1 Chain (2099-2103) (human) Laminin Fragments Catalog

CAS	148498-78-6
Sequence	H-Ile-Lys-Val-Ala-Val-OH
Sequence Single	IKVAV
Molecular Formula	C25H48N6O6
Molecular Weight	131167-89-0
Synonyms	Laminin α-1 Chain (2100-2104) (mouse)
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Alzheimer’s Disease\|Cancer Research\|Regenerative Medicine
Description	Laminin α-1 Chain (2099-2103) (human) also called Laminin α-1 Chain (2100-2104) (mouse), is the laminin core domain with the sequence of IKVAV, it mediates cell adhesion. Often employed for the modification of surfaces improving biocompatibility. In particular, Laminin α-1 Chain (2099-2103) stimulates attachment and growth of neural stem cells.
References	1. Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate. G.B.Stroup et al., J. Bone Miner. Res., 16, 1739 (2001) 2. Selective differentiation of neural progenitor cells by high-epitope density nanofibers. G.A.Silva et al., Science, 303, 5662 (2004) 3. Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension. J.C.Schense et al., Nat. Biotechnol., 18, 415 (2000) 4. beta-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin. M.C.Kibbey et al., Proc. Natl. Acad. Sci. USA, 90, 10150 (1993) 5. Gallium nitride is biocompatible and non-toxic before and after functionalization with peptides. S.A.Jewett et al., Acta Biomater., 8, 728 (2012) 6. Engineering three-dimensional collagen-IKVAV matrix to mimic neural microenvironment. H.Hosseinkhani et al., ACS Chem. Neurosci., 4, 1229 (2013) 7. Materials science. Smart biomaterials. D.G.Anderson et al., Science, 305, 1923 (2004) 8. Bifunctional Hydrogels Containing the Laminin Motif IKVAV Promote Neurogenesis. A.Farrukh et al., Stem Cell Reports, 9, 1432 (2017) 9. Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering. T.Y.Cheng et al., Biomaterials, 34, 2005 (2013)

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Laminin α-1 Chain (2099-2103) (human)

CAS No.: 148498-78-6