| CAS | 65189-71-1 |
| Sequence | H-Leu-Arg-Arg-Ala-Ser-Leu-Gly-OH |
| Sequence Single | LRRASLG |
| Molecular Formula | C32H61N13O9 |
| Molecular Weight | 771.92 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Kemptide is a synthetic heptapeptide that acts as a specific substrate for cAMP-dependent protein kinase (PKA). |
| References | 1. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. S.E.Girardin et al., J. Biol. Chem., 278, 8869 (2003) 2. Participation of ADP dissociation in the rate-determining step in cAMP-dependent protein kinase. J.Zhou and J.A.Adams, Biochemistry, 36, 15733 (1997) 3. Studies on the kinetic mechanism of the catalytic subunit of the cAMP-dependent protein kinase. S.Whitehouse et al., J. Biol. Chem., 258, 3693 (1983) 4. Inhibition of protein kinase C by the tyrosine kinase inhibitor erbstatin. W.R.Bishop et al., Biochem. Pharmacol., 40, 2129 (1990) 5. Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor. E.J.Baude et al., J. Biol. Chem., 269, 2316 (1994) 6. Evidence for ecto-protein kinase activity that phosphorylates Kemptide in a cyclic AMP-dependent mode. Kübler D, et al. J Biol Chem. 1989 Aug 25;264(24):14549-55. 7. Transducin-like enhancer of split-6 (TLE6) is a substrate of protein kinase A activity during mouse oocyte maturation. Duncan FE, et al. Biol Reprod. 2014 Mar 20;90(3):63. |