| CAS | 139026-66-7 |
| Sequence | H-Lys-psi(CH2NH)Lys-Pro-Tyr-Ile-Leu-OH |
| Sequence Single | K-psi(CH2NH)KPYIL |
| Molecular Formula | C38H66N8O7 |
| Molecular Weight | 746.99 |
| Synonyms | (Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13), (Lys8-acetyl-Lys9)-Neurotensin (8-13) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cancer Research |
| Description | JMV 449 also called (Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13), (Lys8-acetyl-Lys9)-Neurotensin (8-13), is a potent neurotensin receptor agonist. JMV 449 shows an IC50 of 0.15 nM for inhibition of [125I]-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse. |