| CAS | 129536-23-8 |
| Sequence | Cyclo(-Pro-Pro-Tyr-Val-Pro-Leu-Ile-Ile) |
| Sequence Single | c(PPYVPLII) |
| Molecular Formula | C47H72N8O9 |
| Molecular Weight | 893.14 |
| Synonyms | HS-I |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Immunomodulating Agents |
| Description | Hymenistatin I (HS-I) exerts an immunosuppressive effect in the humoral and cellular immune responses comparable with that of cyclosporin A (CsA). Comparison of the influence of HS-I and CsA on cytokine production suggests that the mechanisms of the interaction with the immunological system are substantially different for the two compounds tested. |
| References | 1. Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library. R.A.Puras Lutzke, Proc. Natl. Acad. Sci. USA, 92, 11456 (1995) |