| CAS | 208041-90-1 |
| Sequence | H-Arg-Ser-Arg-Thr-Arg-Gln-Phe-Tyr-Gly-Leu-Met-NH2 |
| Sequence Single | RSRTRQFYGLM-NH2 |
| Molecular Formula | C61H100N22O15S |
| Molecular Weight | 1413.67 |
| Synonyms | HEK-1 (mouse, rat), HK-1 (mouse, rat) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Hemokinin 1 (mouse, rat) also called HEK-1 (mouse, rat), HK-1 (mouse, rat), is encoded by the preprotachykinin C (PPT-C) gene, which could be identified in hematopoietic cells in mouse. Hemokinin 1 is a full agonist of all known three tachykinin NK1, NK2, and NK3 receptors with a remarkable selectivity for the NK1 receptor, with Ki of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively. In in vivo experiments it acts with potency similar to substance P. |
| References | 1. Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides. L.A.Dickinson et al., Biochemistry, 38, 10801 (1999) 2. Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Y.Zhang et al., Nat. Immunol., 1, 392 (2000) 3. Hemokinin 1 is a full agonist at the substance P receptor. O.Morteau et al., Nat. Immunol., 2, 1088 (2001) 4. Pharmacological profile of the novel mammalian tachykinin, hemokinin 1. Francesca Bellucci, et al. Br J Pharmacol. 2002 Jan; 135(1): 266-274 |