H-Val-Pro-Leu-Ser-Leu-Tyr-Ser-Gly-OH Matrix Metalloproteinase Catalog

CAS	425632-67-3
Sequence	H-Val-Pro-Leu-Ser-Leu-Tyr-Ser-Gly-OH
Sequence Single	VPLSLYSG
Molecular Formula	C39H62N8O12
Molecular Weight	834.96
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Cancer Research
Description	H-Val-Pro-Leu-Ser-Leu-Tyr-Ser-Gly-OH is cleaved by MMP-2, MMP-7 and MMP-9. For MMP-2, a mid-rate kcat/KM 61,000 ± 4,000 M-1s-1 was determined, for MMP-7 22,000 ± 3,000, and for MMP-9 49,000 ± 3,000.
References	1. Chemical functionalization of graphene enabled by phage displayed peptides. Y.Cui et al., Nano Lett. , 10, 4559 (2010) 2. Temporally tunable, enzymatically responsive delivery of proangiogenic peptides from poly(ethylene glycol) hydrogels. A.H.van Hove et al., Adv. Healthc. Mater., 4, 2002 (2015) 3. Determination of protease cleavage site motifs using mixture-based oriented peptide libraries. B.E.Turk et al., Nat. Biotechnol., 19, 661 (2001) 4. Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2. J.Patterson et al., Biomaterials, 30, 7836 (2010)

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