| CAS | 36099-95-3 |
| Sequence | H-Trp-Glu-OH |
| Sequence Single | WE |
| Molecular Formula | C16H19N3O5 |
| Molecular Weight | 333.34 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Di- and Tripeptides |
| Description | H-Trp-Glu-OH is a selective, reversible and cell-permeable PPARγ with a Kd of ~8 µM. H-Trp-Glu-OH might be developed as a possible lead compound in diabetes research. |
| References | 1. Extremely selective Mg(ClO4)2 mediated removal of Bpoc/Ddz moieties suitable for the solid phase peptide synthesis of thioxo peptides. D.Wildemann et al., Chem. Commun., 1809 (1999) 2. The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARgamma: bioassay with molecular modeling simulation. Ye F, et al. Chembiochem. 2006 Jan;7(1):74-82. |