| CAS | 18684-24-7 |
| Sequence | H-Pro-Hyp-OH |
| Sequence Single | P-Hyp |
| Molecular Formula | C10H16N2O4 |
| Molecular Weight | 228.25 |
| Synonyms | Dipeptide-6 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cell Culture|Cosmetic Peptides & Dermatology|Di- and Tripeptides|Food Research & Nutrition |
| Description | According to Shigemura et al. H-Pro-Hyp-OH is a food-derived collagen peptide in human blood, it stimulates the growth of fibroblasts from mouse skin. Nakatani et al. observed a chondroprotective effect of the dipeptide in mouse articular cartilage. Inoue et al. showed in a clinical study that ingestion of the dipeptides Hyp-Gly and H-Pro-Hyp-OH could improve facial skin moisture and elasticity and reduce facial ageing. |
| References | 1. Kinetics of inhibition of Aeromonas aminopeptidase by leucine methyl ketone derivatives. C.Kettner et al., Arch. Biochem. Biophys., 165, 739 (1974) 2. Effect of Prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin. Y.Shigemura et al., J. Agric. Food Chem., 57, 444 (2009) 3. Chondroprotective effect of the bioactive peptide prolyl-hydroxyproline in mouse articular cartilage in vitro and in vivo. S.Nakatani et al., Osteoarthritis Cartilage, 17, 1620 (2009) 4. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. K.Iwai et al., J. Agric. Food Chem., 53, 6531 (2005) |