| CAS | 36077-41-5 |
| Sequence | H-Leu-Ile-OH |
| Sequence Single | LI |
| Molecular Formula | C12H24N2O3 |
| Molecular Weight | 244.33 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Alzheimer’s Disease|Di- and Tripeptides|Food Research & Nutrition|Regenerative Medicine |
| Description | According to Nitta et al. H-Leu-Ile-OH protects against neuronal death by inducing brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis. Alkam et al. observed that dietary supplementation with the hydrophobic dipeptide prevents the impairment of memory induced by amyloid β in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase. H-Leu-Ile-OH forms nanotubes in the presence of D-leucine. |
| References | 1. Discovery of salt taste enhancing arginyl dipeptides in protein digests and fermented fish sauces by means of a sensomics approach. A.Schindler et al., J. Agric. Food Chem., 59, 12578 (2011) 2. An analog of a dipeptide-like structure of FK506 increases glial cell line-derived neurotrophic factor expression through cAMP response element-binding protein activated by heat shock protein 90/Akt signaling pathway. X.Cen et al., J. Neurosci., 26, 3335 (2006) 3. Hydrophobic dipeptide Leu-Ile protects against neuronal death by inducing brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis. A.Nitta et al., J. Neurosci. Res., 78, 250 (2004) 4. Template-directed supramolecular assembly of a new type of nanoporous peptide-based material. C.H.Görbitz and F.Rise, J. Pept. Sci., 14, 210 (2008) |