| CAS | 22951-98-0 |
| Sequence | H-Ile-Phe-OH |
| Sequence Single | IF |
| Molecular Formula | C15H22N2O3 |
| Molecular Weight | 278.35 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Alzheimer’s Disease|Di- and Tripeptides |
| Description | H-Ile-Phe-OH is a dipeptide able to self-associate in aqueous solution as a transparent, thermoreversible gel formed by a network of fibrillar nanostructures that exhibit strong birefringence upon Congo red binding. This compound and similar dipeptides may serve as models for studying the first steps of the aggregation/fibrillation of amyloid peptides. |
| References | 1. Properties of the single sulfhydryl group of carboxypeptidase Y. Effects of alkyl and aromatic mercurials on activities toward various synthetic substrates. Y.Bai and R.Hayashi, J. Biol. Chem., 254, 8473 (1979) 2. Ile-phe dipeptide self-assembly: clues to amyloid formation. N.S.de Groot et al., Biophys. J., 92, 1732 (2007) |