| CAS | 258338-12-4 |
| Sequence | H-Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH |
| Sequence Single | GSS(octanoyl)FLSPEHQKAQQRKESKKPPAKLQPR |
| Molecular Formula | C147H245N45O42 |
| Molecular Weight | 3314.84 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Diabetes|Obesity Research |
| Description | Ghrelin, a peptide hormone produced by the stomach oxyntic cells plays a crucial role in appetite regulation. It binds to the growth hormone secretagogue receptor (GHS-R), which stimulates the release of GH. Ghrelin, which promotes food uptake and body weight increase, acts as an antagonist of leptin. Thus, it has become an important tool in obesity research. Additionally, ghrelin is involved in the bone metabolism, in reproduction, and in the immune system. |
| References | 1. Mechanism of the reaction catalyzed by isoaspartyl dipeptidase from Escherichia coli. R.Marti-Arbona et al., Biochemistry, 44, 7115 (2005) 2. Ghrelin action in the brain controls adipocyte metabolism. C.Theander-Carrillo et al., J. Clin. Invest., 116, 1983 (2006) 3. Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice. A.M.Shaw et al., Peptides, 26, 1720 (2005) 4. Dose-dependent inhibition by ghrelin of insulin secretion in the mouse. M.K.Reimer et al., Endocrinology, 144, 916 (2003) 5. Resistance to the orexigenic effect of ghrelin in dietary-induced obesity in mice: reversal upon weight loss. M.Perreault et al., Int. J. Obes. Relat. Metab. Disord., 28, 879 (2004) 6. Role of ghrelin in reproduction. M.C.Garcia et al., Reproduction, 133, 531 (2007) |