| CAS | 72629-65-3 |
| Sequence | H-Tyr-Val-Met-Gly-His-Phe-Arg-Trp-Asp-Arg-Phe-NH2 |
| Sequence Single | YVMGHFRWDRF-NH2 |
| Molecular Formula | C72H97N21O14S |
| Molecular Weight | 1512.76 |
| Synonyms | g-1-MSH, amide |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Pituitary & Hypothalamic Hormones |
| Description | γ1-MSH also called g-1-MSH, amide, has been located in the cryptic region of the ACTH/β-lipotropin precursor protein from the intermediate lobe of bovine pituitary. γ1-MSH is a melanocortin MC3 receptor agonist, with a Ki of 34 nM for the rat MC3 receptor. γ1-MSH displays ~40-fold selectivity over MC4 (Ki=1318 nM). |
| References | 1. Effect of gonadotropin-releasing hormone agonists, nafarelin, buserelin, and leuprolide, on experimentally induced endometriosis in the rat. T.Mizutani et al., Int. J. Fertil. Menopaus. Stud., 40, 106 (1995) 2. Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor. S.Nakanishi et al., Nature, 278, 423 (1979) 3. Synthesis and biological activity of four gamma-melanotropin peptides derived from the cryuptic region of the adrenocorticotropin/beta-lipotropin precursor. N.Ling et al., Life Sci., 25, 1773 (1979) 4. Nucleotide sequence of cloned cDNA for bovine corticotropin-beta-lipotropin precursor. S.Nakanishi et al., Nature, 278, 423 (1979) 5. Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the medial rat brain. Lindblom J, et al. Brain Res. 1998;810(1-2):161-171. doi:10.1016/s0006-8993(98)00918-4. |