| CAS | 2243206-97-3 |
| Sequence | H-Cys((RS)-2,3-di(palmitoyloxy)-propyl)-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe-Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys-OH |
| Sequence Single | Pam2CGDPKHPKSFDYKDDDDK |
| Molecular Formula | C125H198N24O37S |
| Molecular Weight | 2661.15 |
| Synonyms | Fibroblast Stimulating Lipopeptide 1 FLAG-tag |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Immunomodulating Agents |
| Description | FSL-1-FLAG also called Fibroblast Stimulating Lipopeptide 1 FLAG-tag, is a lipopeptide synthesized on the basis of the N-terminal structure of a M. salivarium lipoprotein, it is capable of inducing the cell surface expression of ICAM-1 in human gingival fibroblasts. It furthermore revealed an activity to induce production of monocyte chemoattractant protein 1, interleukin-6 (IL-6), and IL-8. FSL-1-FLAG also activated macrophages to produce tumor necrosis factor alpha. Overall, results by Okusawa and coworkers suggest that the diacylglyceryl and the peptide portions of FSL-1 are indispensable for the expression of biological activities and for the recognition by Toll-like receptors 2 and 6. Furthermore, the same authors conclude that the recognition of FSL-1 by Toll-like receptors 2 and 6 apparently is hydrophobic. |
| References | 1. Coupling tumor necrosis factor-alpha with alphaV integrin ligands improves its antineoplastic activity. F.Curnis et al., Cancer Res., 64, 565 (2004) |