| CAS | 74381-53-6 |
| Sequence | Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt |
| Sequence Single | Pyr-HWSYlLRP-NHEt |
| Molecular Formula | C59H84N16O12 |
| Molecular Weight | 1209.42 |
| Synonyms | Leuprolide, Leuprorelin, [Des-Gly10, DLeu6, Pro9] LH-RH, Ethyl Amide |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cancer Research|Pituitary & Hypothalamic Hormones|Veterinary Medicine |
| Description | (Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH also called Leuprolide, Leuprorelin, [Des-Gly10, DLeu6, Pro9] LH-RH, Ethyl Amide, a highly active LHRH (GnRH) agonist stimulates the pituitary release of luteinizing hormone, causing an increase in testicular androgen production. Thus, leuprolide represents a safer alternative to estrogens, and may be preferred in the treatment of men with advanced prostate cancer. CAS Number (net): 53714-56-0. |
| References | 1. Gonadotropin-releasing hormones I and II induce apoptosis in human granulosa cells. I.S.Hong et al., J. Clin. Endocrinol. Metab., 93, 3179 (2008) 2. Effect of leuprolide and cetrorelix on cell growth, apoptosis, and GnRH receptor expression in primary cell cultures from human prostate carcinoma. E.Castellón et al., Cancer Invest., 24, 261 (2006) 3. Leuprorelin. A review of its pharmacology and therapeutic use in prostatic disorders. P.Chrisp and E.M.Sorkin, Drugs & Aging, 1, 487 (1991) 4. Gonadotrophin releasing hormone analogues. D.H.Coy and A.V.Schally, Ann. Clin. Res., 10, 139 (1978) 5. Characterization of the solution conformations of leuprolide acetate. Merck Index, 15th ed., No. 5509, (2013) 6. Cell growth effects of leuprolide on cultured endometrioma cells. J.D.Meyer et al., J. Pept. Res., 60, 159 (2002) 7. Gonadotrophin releasing hormone analogues. D.Levine et al., J. Reprod. Med., 52, 581 (2007) 8. Effect of gonadotropin-releasing hormone agonists, nafarelin, buserelin, and leuprolide, on experimentally induced endometriosis in the rat. D.H.Coy and A.V.Schally, Ann. Clin. Res., 10, 139 (1978) 9. Evidence for hormone-responsive cleavage of gonadotropin-releasing hormone by the plasma membrane of ovarian cancer cells. T.Mizutani et al., Int. J. Fertil. Menopaus. Stud., 40, 106 (1995) |
(Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH
CAS No.: 74381-53-6
(Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH also called Leuprolide, Leuprorelin, [Des-Gly10, DLeu6, Pro9] LH-RH, Ethyl Amide, a hi
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