DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS

CAS No.: 263718-22-5

DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a useful FRET substrate for a continuous fluorescence-based assay of the

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CAS	263718-22-5
Sequence	DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS
Sequence Single	DABCYL-ER-Nle-FLSFP-EDANS
Molecular Formula	C76H98N16O15S
Molecular Weight	1507.78
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Description	DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a useful FRET substrate for a continuous fluorescence-based assay of the malaria aspartyl protease (plasmepsin). The peptide sequence ER-Nle-FLSFP is derived from the cleavage site present in hemoglobin, with Nle as a substitution for Met to avoid potential oxidation related problems.
References	1. New class of small nonpeptidyl compounds blocks Plasmodium falciparum development in vitro by inhibiting plasmepsins. S Jiang, et al. Antimicrob Agents Chemother. 2001 Sep;45(9):2577-84.

H(-Asn-Pro-Asn-Ala)6-OH

H-Gly-Asp-Arg-Ala-Asp-Gly-Gln-Pro-Ala-Gly-Asp-Arg-Ala-Asp-Gly-Gln-Pro-Ala-OH