(D-Arg1,D-Pro2,D-Trp7.9,Leu11)-Substance P Substance P, Fragments, Analogs, and Antagonists Catalog

CAS	84676-91-5
Sequence	H-D-Arg-D-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2
Sequence Single	rpKPQQwFwLL-NH2
Molecular Formula	C75H108N20O13
Molecular Weight	1497.81
Synonyms	[DArg1, DPro2, DTrp7,9, Leu11] Substance P
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Cancer Research
Description	(D-Arg1,D-Pro2,D-Trp7.9,Leu11)-Substance P also called [DArg1, DPro2, DTrp7,9, Leu11] Substance P, is a potent antagonist for substance P and bombesin.
References	1. Central administration of dipeptides, beta-alanyl-BCAAs, induces hyperactivity in chicks. Y.Tsuneyoshi et al., BMC Neurosci., 8, 37 (2007) 2. Bombesin and bombesin antagonists: studies in Swiss 3T3 cells and human small cell lung cancer. P.J.Woll and E.Rozengurt, Br. J. Cancer, 57, 579 (1988) 3. Effects of the substance P antagonist, (D-Arg1, D-Pro2, D-Trp7,9, Leu11)-SP on the miotic response to substance P, antidromic trigeminal nerve stimulation, capsaicin, prostaglandin E1, compound 48/80 and histamine. A.Mandahl and A.Bill, Acta Physiol. Scand., 120, 27 (1984) 4. Interaction of a substance P agonist and of substance P antagonists with lipid membranes. A thermodynamic analysis. Seelig A. Biochemistry. 1992 Mar 24;31(11):2897-904.

PeptideDB