| CAS | 1030384-98-5 |
| Sequence | (H-Lys-Gly-Val-Ser-Leu-Ser-Tyr-Arg)2-Lys-NH2 |
| Sequence Single | (KGVSLSYR)2K-NH2 |
| Molecular Formula | C86H147N27O23 |
| Molecular Weight | 1927.27 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | CTCE-9908 is a potent and selective CXCR4 antagonist. CTCE-9908 induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells. |
| References | 1. An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. Kwong et al (2009). Mol.Cancer Ther. 8 1893 PMID: 19567818 2. CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or doce. in a transgenic mouse model. Hassan et al (2011). Int.J.Cancer. 129 225 PMID: 20830712 3. The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells. Faber et al (2007). J.Biomed.Biotechnol. 2007 26065 PMID: 17541466 |