| CAS | 127060-75-7 |
| Sequence | N-α-Nicotinoyl-Tyr-Lys(N-α-Z-Arg)-His-Pro-Ile-OH |
| Sequence Single | N-α-Nicotinoyl-YK(N-α-Z-Arg)-HPI |
| Molecular Formula | C52H69N13O11 |
| Molecular Weight | 1052.2 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | CGP 42112 is a selective, high affinity angiotensin AT2 receptor ligand (Ki = 0.24 nM). CGP 42112 displays agonistic properties at proximal tubule AT2 receptors, causes Na+, K+-ATPase inhibition and sodium excretion. CGP 42112 antagonizes Ang-II induced contractions in rabbit aortic rings (IC50 = 1850 nM). |
| References | 1. The role of angiotensin receptor subtypes in cerebrovascular regulation in the rat. Naveri (1995). Acta.Physiol.Scand.Suppl. 630 1 PMID: 8610501 2. Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway. Hakam and Hussain (2006). Am.J.Physiol.Renal Physiol. 290 F1430 PMID: 16380464 |