| CAS | 501036-69-7 |
| Sequence | H-Leu-Glu-Asn-Pro-Ser-Pro-Gln-Ala-Pro-Ala-Arg-Arg-Leu-Leu-Pro-Pro-OH |
| Sequence Single | LENPSPQAPARRLLPP |
| Molecular Formula | C78H130N24O22 |
| Molecular Weight | 1756.03 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | BigLEN (mouse) is a potent and selective agonist of orphan G protein-coupled receptor 171 (GPR171), with a Kd of ~0.5 nM. BigLEN (mouse) is a proSAAS-derived neuropeptide. BigLEN (mouse) regulates food intake in mice. BigLEN (mouse) inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynaptic G proteins. |
| References | 1. ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake. Wardman et al (2011). PLoS One 6 e28152 PMID: 22164236 2. Neuropeptide PEN and its receptor GPR83: distribution, signaling, and regulation. Mack et al (2019). ACS Chem.Neurosci. 10 1884 PMID: 30726666 |