| CAS | 72122-62-4 |
| Sequence | H-Tyr-Pro-Phe-Pro-Gly-Pro-Ile-OH |
| Sequence Single | YPFPGPI |
| Molecular Formula | C41H55N7O9 |
| Molecular Weight | 789.93 |
| Synonyms | β-Casomorphin-7 (bovine), β-Casomorphin (1-7), bovine, BCM-7 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Opioid Research |
| Description | β-Casomorphin (bovine) also called β-Casomorphin-7 (bovine), β-Casomorphin (1-7), bovine, BCM-7, has first been isolated from an enzymatic casein digest. Only cow casein variants A1 and B yield this bioactive peptide after in vitro digestion with intestinal enzymes, but not the common A2 variant. β-Casomorphin displays opioid properties, with an IC50 of 14 μM in an Opioid receptors binding assay. The β-casomorphin generated by digestion of bovine milk could play a role in the aetiology of human diseases as type 1 diabetes and cardiovascular affections. In a rat model, β-Casomorphin attenuated the development of nephropathy in type I diabetes via inhibition of epithelial-mesenchymal transition of renal tubular epithelial cells. |
| References | 1. Different proteasome subtypes in a single tissue exhibit different enzymatic properties. B.Dahlmann et al., J. Mol. Biol., 303, 643 (2000) 2. β-Casomorphin-7 attenuates the development of nephropathy in type I diabetes via inhibition of epithelial-mesenchymal transition of renal tubular epithelial cells. W.Zhang et al., Peptides, 36, 186 (2012) 3. Novel opioid peptides derived from casein (beta-casomorphins). I. Isolation from bovine casein peptone. V.Brantl et al., Hoppe-Seyler’s Z. Physiol. Chem., 360, 1211 (1979) 4. The A2 milk case: a critical review. A.S.Truswell, Eur. J. Clin. Nutr., 59, 623 (2005) 5. Polymorphism of bovine beta-casein and its potential effect on human health. S.Kaminski et al., J. Appl. Genet., 48, 189 (2007) |