| CAS | 183241-31-8 |
| Sequence | D-Tyr-Gln-Trp-Ala-Val-β-Ala-His-Phe-Nle-NH2 |
| Sequence Single | D-Tyr-QWAV-β-Ala-HF-Nle-NH2 |
| Molecular Formula | C57H76N14O11 |
| Molecular Weight | 1133.32 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | BA 1 is a potent bombesin receptor agonist (IC50 values are 0.26, 1.55 and 2.52 nM for BB1, BB2 and BB3 respectively). BA 1 enhances glucose transport in obese and diabetic primary myocytes. BA 1 also stimulates NCI-H1299 lung cancer cell proliferation in vitro. |
| References | 1. Effect of bombesin receptor subtype-3 and its synthetic agonist on signaling, glucose transport and metabolism in myocytes from patients with obesity and type 2 diabetes Int. González et al (2015). J.Mol.Med. 35 925 PMID: 25653074 2. ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. Moody et al (2015). Peptides 64 55 PMID: 25554218 3. Comparative pharmacology of bombesin receptor subtype-3, nonpeptide agonist MK-5046, a universal peptide agonist, and peptide antagonist Bantag-1 for human bombesin receptors. Moreno et al (2013). J.Pharmacol.Exp.Ther. 347 100 PMID: 23892571 4. Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors. Mantey et al (1997). J Biol Chem. 272 26062 PMID: 9325344 |