| CAS | 89213-87-6 |
| Sequence | H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bond) |
| Sequence Single | SLRRSSCFGGRMDRIGAQSGLGCNSFRY |
| Molecular Formula | C127H203N45O39S3 |
| Molecular Weight | 3080.49 |
| Synonyms | αhANF, Carperitide, Atrial Natriuretic Peptide (ANP) (1-28) alpha, canine, human, ovine |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cardiovascular System & Diseases|Regenerative Medicine |
| Description | Atrial Natriuretic Factor (1-28) (human) also called αhANF, Carperitide, Atrial Natriuretic Peptide (ANP) (1-28) alpha, canine, human, ovine, is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) inhibits endothelin-1 secretion in a dose-dependent way. |
| References | 1. Synthesis and application of acid labile anchor groups for the synthesis of peptide amides by Fmoc-solid-phase peptide synthesis. G.Breipohl et al., Int. J. Pept. Protein Res., 34, 262 (1989) 2. Natriuretic peptides: an update on bioactivity, potential therapeutic use, and implication in cardiovascular diseases. S.Rubattu et al., Am. J. Hypertens., 21, 733 (2008) 3. Different factors affecting human ANP amyloid aggregation and their implications in congestive heart failure. L.Millucci et al., PLoS One, 6, e21870 (2011) 4. Natriuretic peptides as therapeutic targets. S.Mukaddam-Daher, Expert Opin. Ther. Targets, 10, 239 (2006) 5. Natriuretic peptides in the diagnosis and management of heart failure. G.M.Felker et al., CMAJ, 175, 611 (2006) 6. Atrial and brain natriuretic peptides inhibit the endothelin-1 secretory response to angiotensin II in porcine aorta. Kohno M, et al. Circ Res. 1992 Feb;70(2):241-7. 7. Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells. Kohno M, et al. J Clin Invest. 1991 Jun;87(6):1999-2004. 8. Physiologic regulation of atrial natriuretic peptide receptors in rat renal glomeruli. Ballermann BJ, et al. J Clin Invest. 1985 Dec;76(6):2049-56. |
Atrial Natriuretic Factor (1-28) (human)
CAS No.: 89213-87-6
Atrial Natriuretic Factor (1-28) (human) also called αhANF, Carperitide, Atrial Natriuretic Peptide (ANP) (1-28) alpha,
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