(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) pTH and pTH-Related Protein Catalog

CAS	129622-68-0
Sequence	H-Leu-Leu-His-Asn-Leu-D-Trp-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-NH2
Sequence Single	LLHNLwKSIQDLRRRFFLHHLIAEIHTA-NH2
Molecular Formula	C162H254N50O36
Molecular Weight	3478.11
Synonyms	(Asn10,Leu11,D-Trp12)-Hypercalcemia of Malignancy Factor (7-34) amide (human, mouse, rat)
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Description	(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) also called (Asn10,Leu11,D-Trp12)-Hypercalcemia of Malignancy Factor (7-34) amide (human, mouse, rat), is a pTHrP (7-34) amide analog. It was found to be an effective antagonist of pTH-stimulated cAMP production in ROS cells and was shown not to display partial agonism.
References	1. Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro. N.Horiuchi et al., Science, 238, 1566 (1987) 2. Removal of partial agonism from parathyroid hormone (PTH)-related protein-(7-34)NH2 by substitution of PTH amino acids at positions 10 and 11. R.F.Nutt et al., Endocrinology, 127, 491 (1990)

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