| CAS | 212370-59-7 |
| Sequence | Ac-Cys-Nle-Arg-His-D-2-Nal-Arg-Trp-Gly-Cys-NH2 (Disulfide bond) |
| Sequence Single | Ac-C-Nle-RH-D-2-Nal-RWGC-NH2 (Disulfide bond) |
| Molecular Formula | C58H79N19O10S2 |
| Molecular Weight | 1266.52 |
| Synonyms | HS024 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Obesity Research|Pituitary & Hypothalamic Hormones |
| Description | Acetyl-(Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-MSH (3-11) amide also called HS024, showed about 20-fold selectivity and very high affinity (Ki = 0.29 nM) for the melanocortin-4 (MC4) receptor and also increased the food intake, indicating that blockade of the MC4 receptor is a highly effective way to increase feeding. For MC4, MC5, MC3, and MC1, Ki is 0.29, 3.29, 5.45, and 18.6 nM respectively. |
| References | 1. Design and function of novel osteoblast-adhesive peptides for chemical modification of biomaterials. K.C.Dee et al., J. Biomed. Mater Res., 40, 371 (1998) 2. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Kask A, et al. Endocrinology. 1998;139(12):5006-5014. |
Acetyl-(Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-MSH (3-11) amide
CAS No.: 212370-59-7
Acetyl-(Cys3,Nle4,Arg5,D-2-Nal7,Cys11)-α-MSH (3-11) amide also called HS024, showed about 20-fold selectivity and very
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