| CAS | 159439-02-8 |
| Sequence | Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH |
| Sequence Single | Ac-(p)YEEIE |
| Molecular Formula | C32H46N5O17P |
| Molecular Weight | 803.71 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Growth Factors|Protein-Tyrosine Kinases |
| Description | Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH showed high affinity for the pp60src SH2 domain with an IC50 = 0.5 µM. Additionally it blocked binding of various SH2 domain constructs to platelet-derived growth factor kinase, i.e. Src with IC50 = 1.35 µM, Abl with IC50 = 15.3 µM and Grb2 at 100 µM by 44.25%. It did not bind to Syp (N-terminal) and PLC (C-terminal) SH2 constructs. |
| References | 1. Potent dipeptide inhibitors of the pp60c-src SH2 domain. G J Pacofsky, et al. J Med Chem. 1998 May 21;41(11):1894-908. |
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH
CAS No.: 159439-02-8
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH showed high affinity for the pp60src SH2 domain with an IC50 = 0.5 µM. Additionally it
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