| CAS | 353487-64-6 |
| Sequence | Ac-Arg-Cys-Met-Ava-Arg-Val-Tyr-Ava-Cys-NH2 (Disulfide bond) |
| Sequence Single | Ac-RCM-Ava-RVY-Ava-C-NH2 |
| Molecular Formula | C49H82N16O11S3 |
| Molecular Weight | 1167.49 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Pituitary & Hypothalamic Hormones |
| Description | Ac-Arg-Cys-Met-5-aminopentanoyl-Arg-Val-Tyr-5-aminopentanoyl-Cys-NH2 (Disulfide bond) is a full competitive MCH-1 receptor antagonist devoid of agonist potency for the human MCH-1 receptor even at micromolar concentrations (Kb = 3.6 nM). |
| References | 1. BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors. D.Andrau et al., J. Biol. Chem., 278, 25859 (2003) 2. Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats. L.P.Shearman et al., Eur. J. Pharmacol., 475, 37 (2003) |
Ac-Arg-Cys-Met-5-aminopentanoyl-Arg-Val-Tyr-5-aminopentanoyl-Cys-NH2 (Disulfide bond)
CAS No.: 353487-64-6
Ac-Arg-Cys-Met-5-aminopentanoyl-Arg-Val-Tyr-5-aminopentanoyl-Cys-NH2 (Disulfide bond) is a full competitive MCH-1 recept
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