| CAS | 19245-85-3 |
| Sequence | Ac-Ala-Ala-Ala-OH |
| Sequence Single | Ac-AAA |
| Molecular Formula | C11H19N3O5 |
| Molecular Weight | 273.29 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Di- and Tripeptides |
| Description | Ac-Ala-Ala-Ala-OH is a suitable substrate for acylaminoacyl peptidase (N-acyl-peptide hydrolase). This enzyme releases acylamino acids from N-acylated peptides and may therefore play a role in protein degradation. |
| References | 1. Stimulation of Na+/Cl--coupled opioid peptide transport system in SK-N-SH cells by L-kyotorphin, an endogenous substrate for H+-coupled peptide transporter PEPT2. S.V.Thakkar et al., Drug Metab. Pharmacokinet., 23, 254 (2008) 2. Specificity determinants of acylaminoacyl-peptide hydrolase. Mammalian Proteases, Vol. 2: Exopeptidases, p. 341, J.K.McDonald and A.J.Barrett, eds., Academic Press, London, (1986) 3. Enzymic cleavage of the blocked amino terminal residues of peptides. R.G.Krishna and F.Wold, Protein Sci., 1, 582 (1992) 4. Purification and partial characterization of alpha-N-acylpeptide hydrolase from bovine liver. W.M.Jones et al., Biochem. Biophys. Res. Commun., 139, 244 (1986) |