6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) Toxins Catalog

CAS	1927927-42-1
Sequence	Fluorescein-6-carbonyl-AEEAc-Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys-OH (Disulfide bonds between Cys3 and Cys35/Cys12 and Cys28/Cys17 and Cys32)
Sequence Single	Fluorescein-6-carbonyl-AEEAc-RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC
Molecular Formula	C196H295N55O57S7
Molecular Weight	4558.3
Synonyms	6-FAM-AEEAc-ShK, ShK-F6CA
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Ion Channel Modulating Agents
Description	6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) also called 6-FAM-AEEAc-ShK, ShK-F6CA, is a ShK analog containing a fluorescein-6-carboxyl group attached through an {2-[2-aminoethoxy]ethoxy}acetic acid (AEEAc) linker to the ƒ-amino group of Arg1, it selectively blocked the voltage gated T-lymphocyte K+ Kv1.3 channels implicated in the pathogenesis of experimental autoimmune encephalomyelitis. It potently blocked Kv1.3 channels at picomolar concentrations and exhibited >80 fold specificity for Kv1.3 over Kv1.1 and other Kv channels. In flow cytometry experiments, chronically activated rat and human T-lympocytes with >600 Kv1.3 channels/cell were readily distinguished from resting and acutely activated T-lymphocytes with lower Kv1.3 channel numbers. 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) may therefore be a useful tool to detect the presence of T-lymphocytes with high expression of Kv1.3 channels in normal and diseased tissues.
References	1. In vivo characterization of a phosphoramidon-sensitive endothelin-converting enzyme in the rat. D.M.Pollock et al., Eur. J. Pharmacol., 231, 459 (1993)

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6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK)

CAS No.: 1927927-42-1