| CAS | 955091-53-9 |
| Sequence | H-Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr-OH |
| Sequence Single | WRQAAFVDSY |
| Molecular Formula | C58H79N15O16 |
| Molecular Weight | 1242.37 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | 10Panx is a panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. 10Panx inhibits P2X7-mediated dye uptake, ATP-mediated IL-1β release and caspase-1 activation without altering membrane current in macrophages in vitro. 10Panx also blocks activation of NMDA receptor secondary currents (I2nd) by > 70%. |
| References | 1. Pannexin-1 mediates large pore formation and interleukin-1β; release by the ATP-gated P2X7 receptor. Pelegrin and Surprenant (2006). EMBO J. 25 5071 PMID: 17036048 2. Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Wang et al (2007). Am.J.Physiol.Cell Physiol. 293 C1112 PMID: 17652431 3. Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Thompson et al (2008). Science 322 1555 PMID: 19056988 |