(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. (9R)-RO7185876 inhibits the secretion of Αβ42. (9R)-RO7185876 can be used in the study of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia or Down syndrome.

Physicochemical Properties

Molecular Formula	C25H28F3N7
Molecular Weight	483.53
CAS #	2226077-86-5
Related CAS #	RO7185876
Appearance	Typically exists as solids at room temperature
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Bicyclic heteroaryl derivatives. WO2018083050. WIPO. 2018-05-11.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~206.81 mM; with ultrasonication (<60°C))

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 5 mg/mL (10.34 mM)(saturation unknown) in 10% DMSO 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution and add it to 900 μL of 20% SBE-β-CD saline solution and mix well. 2 g SBE-β-CD (sulfobutyl ether β-cyclodextrin) powder is diluted to 10 mL of saline and completely dissolved until clear and transparent.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.0681 mL	10.3406 mL	20.6812 mL
	5 mM	0.4136 mL	2.0681 mL	4.1362 mL
	10 mM	0.2068 mL	1.0341 mL	2.0681 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.